Marijuana

Marijuana is the most commonly used illicit drug in the United States. A dry, shredded green/brown mix of flowers, stems, seeds, and leaves of the hemp plant Cannabis sativa, it usually is smoked as a cigarette (joint, nail), or in a pipe (bong). It also is smoked in blunts, which are cigars that have been emptied of tobacco and refilled with marijuana, often in combination with another drug. Use also might include mixing marijuana in food or brewing it as a tea. As a more concentrated, resinous form it is called hashish and, as a sticky black liquid, hash oil. Marijuana smoke has a pungent and distinctive, usually sweet-and-sour odor. There are countless street terms for marijuana including pot, herb, weed, grass, widow, ganja, and hash, as well as terms derived from trademarked varieties of cannabis, such as, Northern Lights®, Fruity Juice®, Afghani #1®, and a number of Skunk varieties.

The main active chemical in marijuana is THC (delta-9-tetrahydrocannabinol). The membranes of certain nerve cells in the brain contain protein receptors that bind to THC. Once securely in place, THC kicks off a series of cellular reactions that ultimately lead to the high that users experience when they smoke marijuana.

Extent of Use

There were an estimated 2.6 million new marijuana users in 2001. This number is similar to the numbers of new users each year since 1995, but above the number in 1990 (1.6 million). In 2002, over 14 million Americans age 12 and older used marijuana at least once in the month prior to being surveyed, and 12.2 percent of past year marijuana users used marijuana on 300 or more days in the past 12 months. This translates into 3.1 million people using marijuana on a daily or almost daily basis over a 12-month period(1).

The percentage of youth age 12 to 17 who had ever used marijuana declined slightly from 2001 to 2002 (21.9 to 20.6 percent). Among adults age 18 to 25, the rate increased slightly from 53.0 percent to 53.8 percent in 2002. The percentage of young adults age 18 to 25 who had ever used marijuana was 5.1 percent in 1965, but increased steadily to 54.4 percent in 1982. Although the rate for young adults declined somewhat from 1982 to 1993, it did not drop below 43 percent and actually increased to 53.8 percent by 2002(1).

Forty-two percent of youth age 12 or 13 and 24.1 percent age 16 or 17 perceived smoking marijuana once a month as a great risk. Slightly more than half of youth age 12 to 17 indicated that it would be fairly or very easy to obtain marijuana, but only 26.0 percent of 12- or 13-year-olds indicated the same thing. However, 79.0 percent of those age 16 or 17 indicated that it would be fairly or very easy to obtain marijuana(1).

Prevalence of lifetime, past year, and past month marijuana use declined among students in 8th, 10th, and 12th grades in 2003. However, the declines in 12-month prevalence reached statistical significance only in 8th-graders; past year use has declined by nearly one-third since 1996(2). All three grades showed an increase in perceived risk for regular marijuana use. This finding represents a welcome turnaround in this perception, which has been in decline in all grades over the past 1 or 2 years(3).

In 2002, marijuana was the third most commonly abused drug mentioned in drug-related hospital emergency department (ED) visits in the continental United States. Marijuana mentions rose significantly (24%) from 2000 to 2002, but showed no significant increase since 2001. Taking changes in population into account, marijuana mentions increased 139 percent from 1995 to 2002(4).

Effects on the Brain

Scientists have learned a great deal about how THC acts in the brain to produce its many effects. When someone smokes marijuana, THC rapidly passes from the lungs into the bloodstream, which carries the chemical to organs throughout the body, including the brain.

In the brain, THC connects to specific sites called cannabinoid receptors on nerve cells and influences the activity of those cells. Some brain areas have many cannabinoid receptors; others have few or none. Many cannabinoid receptors are found in the parts of the brain that influence pleasure, memory, thought, concentration, sensory and time perception, and coordinated movement(5).

The short-term effects of marijuana can include problems with memory and learning; distorted perception; difficulty in thinking and problem solving; loss of coordination; and increased heart rate. Research findings for long-term marijuana use indicate some changes in the brain similar to those seen after long-term use of other major drugs of abuse. For example, cannabinoid (THC or synthetic forms of THC) withdrawal in chronically exposed animals leads to an increase in the activation of the stress-response system(6) and changes in the activity of nerve cells containing dopamine(7). Dopamine neurons are involved in the regulation of motivation and reward, and are directly or indirectly affected by all drugs of abuse.

Effects on the Heart

One study has indicated that a user's risk of heart attack more than quadruples in the first hour after smoking marijuana(8). The researchers suggest that such an effect might occur from marijuana's effects on blood pressure and heart rate and reduced oxygen-carrying capacity of blood.

Effects on the Lungs

A study of 450 individuals found that people who smoke marijuana frequently but do not smoke tobacco have more health problems and miss more days of work than nonsmokers(9). Many of the extra sick days among the marijuana smokers in the study were for respiratory illnesses.

Even infrequent use can cause burning and stinging of the mouth and throat, often accompanied by a heavy cough. Someone who smokes marijuana regularly may have many of the same respiratory problems that tobacco smokers do, such as daily cough and phlegm production, more frequent acute chest illness, a heightened risk of lung infections, and a greater tendency to obstructed airways(10). Smoking marijuana increases the likelihood of developing cancer of the head or neck, and the more marijuana smoked the greater the increase(11). A study comparing 173 cancer patients and 176 healthy individuals produced strong evidence that marijuana smoking doubled or tripled the risk of these cancers.

Marijuana use also has the potential to promote cancer of the lungs and other parts of the respiratory tract because it contains irritants and carcinogens(12, 13). In fact, marijuana smoke contains 50 to 70 percent more carcinogenic hydrocarbons than does tobacco smoke(14). It also produces high levels of an enzyme that converts